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SCFAs also act as signaling molecules by activating G-protein coupled receptors (GPCRs) such as GPR41 (FFAR3) and GPR43 (FFAR2) on gut epithelial cells, immune cells, and enteroendocrine cells (133, 134)

in the ACCORD trial, intensified diabetes therapy even increased mortality [18]

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Our previous study has also demonstrated that increased hepatic IRI exaggerates liver tumor progression and increases the likelihood of lung metastasis through activating cell adhesion, invasion, and angiogenesis pathways [6]